Fruit, Vegetable & Nutrient Blends
Acerola & Rose Hips
Aparecida de Assis S et al. Antioxidant activity, ascorbic acid and total phenol of exotic fruits occurring in Brazil. Int J Food Sci Nutr. 2008 Sep 10:1-10 Hanamura T and Aoki H. Toxicological evaluation of polyphenol extract from Acerola (Malpighia emarginata DC.) fruit. J Food Sci. 2008 May;73(4):T55-61.
Hanamura T, Hagiwara T and Kawagishi H. Structural and functional characterization of polyphenols isolated from acerola (Malpighia emarginata DC.) fruit. Biosci Biotechnol Biochem. 2005 Feb;69(2):280-6.
Hanamura T et al. Antihyperglycemic effect of polyphenols from Acerola (Malpighia emarginata DC.) fruit. Biosci Biotechnol Biochem. 2006 Aug;70(8):1813-20. Kawaguchi M, Tanabe H and Nagamine K. Isolation and characterization of a novel flavonoid possessing a 4,2”-glycosidic linkage from green mature acerola (Malpighia emarginata DC.) fruit. Biosci Biotechnol Biochem. 2007 May;71(5):1130-5
Motohashi N et al. Biological activity of barbados cherry (acerola fruits, fruit of Malpighia emarginata DC) extracts and fractions. Phytother Res 18: 212-223, 2004
Wakabayashi H et al. Inhibition of LPS-stimulated NO production in mouse macrophage-like cells by Barbados cherry, a fruit of Malpighia emarginata DC. Anticancer Res. 2003 Jul-Aug;23(4):3237-41.
Ahmet I et al. Survival and cardioprotective benefits of long-term blueberry enriched diet in dilated cardiomyopathy following myocardial infarction in rats. PLoS One. 2009 Nov 19;4(11):e7975.
Bachi D et al. Safety and whole-body antioxidant potential of a novel anthocyanin-rich formulation of edible berries. Mol Cell Biochem. 2006 Jan;281(1-2):197-209.
Borges G et al. Identification of Flavonoid and Phenolic Antioxidants in Black Currants, Blueberries, Raspberries, Red Currants, and Cranberries (dagger). J Agric Food Chem.. [Epub ahead of print]
Duthie SJ. Berry phytochemicals, genomic stability and cancer: evidence for chemoprotection at several stages in the carcinogenic process. Mol Nutr Food Res. 2007 Jun;51(6):665-74
Ferrrara P. Cranberry juice for the prevention of recurrent urinary tract infections: a randomized controlled trial in children. Scand J Urol Nephrol. 2009;43(5):369-72.
Huang C et al. Differential inhibition of UV-induced activation of NF kappa B and AP-1 by extracts from black raspberries, strawberries, and blueberries. Nutr Cancer. 2007;58(2):205-12.
Huang C et al. Black raspberry extracts inhibit benzo(a)pyrene diol-epoxide-induced activator protein 1 activation and VEGF transcription by targeting the phosphotidylinositol 3-kinase/Akt pathway. Cancer Res. 2006 Jan 1;66(1):581-7.
Hurst RD et al. Blueberry fruit polyphenolics suppress oxidative stress-induced skeletal muscle cell damage in vitro. Mol Nutr Food Res. 2009 Nov 2. [Epub ahead of print]
Joseph JA et al. Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model. Nutr Neurosci 2003; 6: 153-162. Karlsen A et al. Bilberry juice modulates plasma concentration of NF-kappaB related inflammatory markers in subjects at increased risk of CVD. Eur J Nutr. 2010 Feb 2. [Epub ahead of print]
Lee IT et al. Effect of cranberry extracts on lipid profiles in subjects with Type 2 diabetes. Diabet Med. 2008 Dec;25(12):1473-7. Li J et al. Differential effects of black raspberry and strawberry extracts on BaPDE-induced activation of transcription factors and their target genes. Mol Carcinog. 2008 Apr;47(4):286-94.
Magarinos HL et al. In vitro inhibitory effect of cranberry (Vaccinium macrocarpom Ait.) juice on pathogenic microorganisms. Prikl Biokhim Mikrobiol. 2008 May-Jun;44(3):333-6.
Mauray A et al. Atheroprotective effects of bilberry extracts in apo E-deficient mice. J Agric Food Chem. 2009;57(23):11106-11.
Matsunaga N et al. Vaccinium myrtillus (Bilberry) Extracts Reduce Angiogenesis In Vitro and In Vivo. Evid Based Complement Alternat Med. 2010; 7(1):47.
Persson IA, Persson K and Andersson RG. Effect of Vaccinium myrtillus and its polyphenols on angiotensin-converting enzyme activity in human endothelial cells. J Agric Food Chem. 2009 Jun 10;57(11):4626-9.
Seeram N. Berry fruits for cancer prevention: current status and future prospects. J Agric Food Chem. 2008 Feb 13;56(3):630-5
Seeram NP et al. Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro. J Agric Food Chem. 2006 Dec 13;54(25):9329-39.
Shaughnessy KS et al. Diets containing blueberry extract lower blood pressure in spontaneously hypertensive stroke-prone rats. Nutr Res. 2009 Feb;29(2):130-8.
Stacewicz-Sapuntzakis M et al. Chemical composition and potential health effects of prunes: a functional food? Crit Rev Food Sci Nutr. 2001 May;41(4):251-86.
Stothers L. A randomized trial to evaluate effectiveness and cost effectiveness of naturopathic cranberry products as prophylaxis against urinary tract infection in women. Can J Urol. 2002 Jun;9(3):1558-62.
Takikawa M et al. Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice. JNutr. 2010;140(3):527-33. Epub 2010 Jan 20.
Torri E et al. Anti-inflammatory and antinociceptive properties of blueberry extract (Vaccinium corymbosum). J Pharm Pharmacol. 2007 Apr;59(4):591-6.
Zafra-Stone S et al. Berry anthocyanins as novel antioxidants in human health and disease prevention. Mol Nutr Food Res. 2007 Jun;51(6):675-83
Inoue T et al. Tropical fruit camu-camu (Myrciaria dubia) has anti-oxidative and anti-inflammatory properties. J Cardiol. 2008 Oct;52(2):127-32
Justi KC et al. Nutritional composition and vitamin C stability in stored camu-camu (Myrciaria dubia) pulp. Arch Latinoam Nutr. 2000 Dec;50(4):405-8.
Zanatta CF et al. Determination of anthocyanins from camu-camu (Myrciaria dubia) by HPLC-PDA, HPLC-MS, and NMR. J Agric Food Chem 2005; 53: 9531-9535.
Aranganathan S et al. Modulatory efficacy of hesperetin (citrus flavanone) on xenobiotic-metabolizing enzymes during 1,2-dimethylhydrazine-induced colon carcinogenesis. Chem Biol Interact. 2009 Jul 15;180(2):254-61
Aranganathan S, Selvam JP and Nalini N. Effect of hesperetin, a citrus flavonoid, on bacterial enzymes and carcinogen-induced aberrant crypt foci in colon cancer rats: a dose-dependent study. J Pharm Pharmacol. 2008 Oct;60(10):1385-92.
Benavente-Garcia O and Castillo J. Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity. J Agric Food Chem. 2008 Aug 13;56(15):6185-205
Benavente-Garcia O et al. Beneficial action of Citrus flavonoids on multiple cancer-related biological pathways. Curr Cancer Drug Targets. 2007 Dec;7(8):795-809.
Garcia-Lafuente A et al. Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease. Inflamm Res. 2009 Sep;58(9):537-52
Manthey JA, Grohmann K, Guthrie N. Biological properties of citrus flavonoids pertaining to cancer and inflammation. Curr Med Chem. 2001 Feb;8(2):135-53.
Middleton E. Effect of plant flavonoids on immune and inflammatory cell function. Adv Exp Med Biol 1998; 439: 175-182
Vinson JA and Bose P. Comparative bioavailability to humans of ascorbic acid alone or in a citrus extract. Am J Clin Nutr 1988; 48: 601-604.
Bagchi D et al. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology 2000; 148: 187-197.
Bagchi D et al. Cellular protection with proanthocyanidins derived from grape seeds. Ann N Y Acad Sci. 2002 May;957:260-70.
Clifton PM. Effect of Grape Seed Extract and Quercetin on Cardiovascular and Endothelial Parameters in High-Risk Subjects. J Biomed Biotechnol 2004: 272-278, 2004.
Del Bas JM et al. Dietary procyanidins lower triglyceride levels signaling through the nuclear receptor small heterodimer partner. Mol Nutr Food Res. 2008 Oct;52(10):1172-81
Dohadwala MM and Vita JA. Grapes and cardiovascular disease. J Nutr. 2009 Sep;139(9):1788S-93S
Kar P et al. Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity. Diabet Med. 2009 May;26(5):526-31.
Kaur M, Agarwal C and Agarwal R. Anticancer and cancer chemopreventive potential of grape seed extract and other grape-based products. J Nutr. 2009 Sep;139(9):1806S-12S
Kaur M et al. Grape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6194-202.
La VD et al. Grape seed extract suppresses lipopolysaccharide-induced matrix metalloproteinase (MMP) secretion by macrophages and inhibits human MMP-1 and -9 activities. J Periodontol. 2009 Nov;80(11):1875-82.
Pezzuto JM. Grapes and human health: a perspective. J Agric Food Chem. 2008 Aug 27;56(16):6777-84
Pezzuto JM et al. Unraveling the relationship between grapes and health. J Nutr. 2009 Sep;139(9):1783S-7S
Sivaprakasapillai B et al. Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome. Metabolism. 2009 Dec;58(12):1743-6
Velmurugan B et al. Dietary feeding of grape seed extract prevents intestinal tumorigenesis in APCmin/+ mice. Neoplasia. 2010 Jan;12(1):95-102.
Wen W et al. Grape seed extract inhibits angiogenesis via suppression of the vascular endothelial growth factor receptor signaling pathway. Cancer Prev Res (Phila Pa). 2008 Dec;1(7):554-61.
Zhang FL, Gao HQ and Shen L. Inhibitory effect of GSPE on RAGE expression induced by advanced glycation end products in endothelial cells. J Cardiovasc Pharmacol. 2007 Oct;50(4):434-40.
Zunino S. Type 2 diabetes and glycemic response to grapes or grape products. J Nutr. 2009 Sep;139(9):1794S-800S
Vegetable & Nutrient Blend
Phillips KM, Carlsen MH and Blomhoff R. Total antioxidant content of alternatives to refined sugar. J Am Diet Assoc. 2009 Jan;109(1):64-71
Nutritional (Vegetarian) Yeast
Donaldson MS. Metabolic vitamin B12 status on a mostly raw vegan diet with follow-up using tablets, nutritional yeast, or probiotic supplements. Ann Nutr Metab. 2000;44(5-6):229-34.
El-Bayoumy K et al. Influence of selenium-enriched yeast supplementation on biomarkers of oxidative damage and hormone status in healthy adult males: a clinical pilot study. Cancer Epidemiol Biomarkers Prev. 2002 Nov;11(11):1459-65.
Moyad MA. Brewer’s/baker’s yeast (Saccharomyces cerevisiae) and preventive medicine: Part I. Urol Nurs. 2007 Dec;27(6):560-1.
Moyad MA. Brewer’s/baker’s yeast (Saccharomyces cerevisiae) and preventive medicine: Part II. Urol Nurs. 2008 Feb;28(1):73-5.
Racek J et al. Influence of chromium-enriched yeast on blood glucose and insulin variables, blood lipids, and markers of oxidative stress in subjects with type 2 diabetes mellitus. Biol Trace Elem Res. 2006 Mar;109(3):215-30.
Vinson JA, Tompkins TA and Agbor GA. Comparative bioavailability of mineral-enriched gluconates and yeast in rat liver after depletion-repletion feeding. Biol Trace Elem Res. 2007 Aug;118(2):104-10.
Organic Olive Extract
Cornwell DG and Ma J. Nutritional benefit of olive oil: the biological effects of hydroxytyrosol and its arylating quinone adducts. J Agric Food Chem. 2008 Oct 8;56(19):8774-86
Jemai H, El Feki A and Sayadi S. Antidiabetic and antioxidant effects of hydroxytyrosol and oleuropein from olive leaves in alloxan-diabetic rats. J Agric Food Chem. 2009 Oct 14;57(19):8798-804.
Readerstorff. Antioxidant Activity of Olive Polyphenols in Humans: a Review. Int J Vitam Nutr Res. 2009 May;79(3):152-165.
Rietjens SJ, Bast A and Haenen G. New insights into controversies on the antioxidant potential of the olive oil antioxidant hydroxytyrosol. J Agric Food Chem. 2007 Sep 5;55(18):7609-14.
Rietjens SJ et al. The olive oil antioxidant hydroxytyrosol efficiently protects against the oxidative stress-induced impairment of the NObullet response of isolated rat aorta. Am J Physiol Heart Circ Physiol. 2007 Apr;292(4):H1931-6.
Visioli F and Galli C. Biological properties of olive oil phytochemicals. Crit Rev Food Sci Nutr. 2002;42(3):209-21.
Vissers MN, Zock PL and Katan M. Bioavailability and antioxidant effects of olive oil phenols in humans: a review. Eur J Clin Nutr. 2004 Jun;58(6):955-65.
Zhu L et al. Hydroxytyrosol protects against oxidative damage by simultaneous activation of mitochondrial biogenesis and phase II detoxifying enzyme systems in retinal pigment epithelial cells. J Nutr Biochem. 2010 Feb 8. [Epub ahead of print]
Ardiansyah et al. Rice bran fractions improve blood pressure, lipid profile, and glucose metabolism in stroke-prone spontaneously hypertensive rats. J Agric Food Chem 54: 1914-1920, 2006.
Fang N et al. Inhibition of growth and induction of apoptosis in human cancer cell lines by an ethyl acetate fraction from shiitake mushrooms. J Altern Complement Med. 2006 Mar;12(2):125-32.
Israilides C et al. In vitro cytostatic and immunomodulatory properties of the medicinal mushroom Lentinula edodes. Phytomedicine. 2008 Jun;15(6-7):512-9
Ko JA et al. Effect of UV-B exposure on the concentration of vitamin D2 in sliced shiitake mushroom (Lentinus edodes) and white button mushroom (Agaricus bisporus). J Agric Food Chem. 2008 May 28;56(10):3671-4.
Kuppusamy UR et al. Lentinula edodes (Shiitake) mushroom extract protects against hydrogen peroxide induced cytotoxicity in peripheral blood mononuclear cells. Indian J Biochem Biophys. 2009 Apr;46(2):161-5.
Ng ML and Yap AT. Inhibition of human colon carcinoma development by lentinan from shiitake mushrooms (Lentinus edodes). J Altern Complement Med. 2002 Oct;8(5):581-9.
Sia GM and Candlish JK. Effects of shiitake (Lentinus edodes) extract on human neutrophils and the U937 monocytic cell line. Phytother Res. 1999 Mar;13(2):133-7.
Basu A and Imrhan V. Tomatoes versus lycopene in oxidative stress and carcinogenesis: conclusions from clinical trials. Eur J Clin Nutr. 2007 Mar;61(3):295-303.
Brooks JD, Paton VG and Vidanes G. Potent induction of phase 2 enzymes in human prostate cells by sulforaphane. Cancer Epidemiol Biomarkers Prev. 2001 Sep;10(9):949-54.
Cornblatt BS et al. Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast. Carcinogenesis. 2007 Jul;28(7):1485-90
Eberhardt MV et al. Correlation analyses of phytochemical composition, chemical, and cellular measures of antioxidant activity of broccoli (Brassica oleracea L. Var. italica). J Agric Food Chem. 2005 Sep 21;53(19):7421-31.
Fahey JW, Zhang Y and Talalay P. Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10367-72.
Galan MV, Kishan AA and Silverman AL. Oral broccoli sprouts for the treatment of Helicobacter pylori infection: a preliminary report. Dig Dis Sci. 2004 Aug;49(7-8):1088-90
Higdon JV et al. Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. Pharmacol Res. 2007 Mar;55(3):224-36
Johnson IT. Glucosinolates: bioavailability and importance to health. Int J Vitam Nutr Res. 2002 Jan;72(1):26-31.
Keck AS and Finley JW. Cruciferous vegetables: cancer protective mechanisms of glucosinolate hydrolysis products and selenium. Integr Cancer Ther. 2004 Mar;3(1):5-12.
Lynn A et al. Cruciferous vegetables and colo-rectal cancer. Proc Nutr Soc. 2006 Feb;65(1):135-44.
Porrini M, Riso P and Oriani G. Spinach and tomato consumption increases lymphocyte DNA resistance to oxidative stress but this is not related to cell carotenoid concentrations. Eur J Nutr. 2002 Jun;41(3):95-100.
Riedl MA, Saxon A and Diaz-Sanchez D. Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway. Clin Immunol. 2009 Mar;130(3):244-51
Talalay P and Fahey JW. Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism. J Nutr. 2001 Nov;131(11 Suppl):3027S-33S.
Vasanthi HR, Mukherjee S and Das DK. Potential health benefits of broccoli- a chemico-biological overview. Mini Rev Med Chem. 2009 Jun;9(6):749-59.
Vivar OI et al. 3,3′-Diindolylmethane induces a G(1) arrest in human prostate cancer cells irrespective of androgen receptor and p53 status. Biochem Pharmacol. 2009 Sep 1;78(5):469-76.
Yanaka A et al. Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. Cancer Prev Res (Phila Pa). 2009 Apr;2(4):353-60.
Yeh CT and Yen GC. Effect of vegetables on human phenolsulfotransferases in relation to their antioxidant activity and total phenolics. Free Radic Res. 2005 Aug;39(8):893-904.
Chidambara Murthy KN, Vanitha A, Rajesha J, Mahadeva SM, Sowmya PR and Ravishankar GA. In vivo antioxidant activity of carotenoids from Dunaliella salina–a green microalga. Life Sci 2005; 76: 1381-1390.
Krinsky NI. The antioxidant and biological properties of the carotenoids. Ann N Y Acad Sci. 1998 Nov 20;854:443-7
Larsson SC, Bergkvist L and Wolk A. Dietary carotenoids and risk of hormone receptor-defined breast cancer in a prospective cohort of Swedish women. Eur J Cancer. 2010 Jan 27. [Epub ahead of print]
Moukarzel AA, Bejjani RA and Fares FN. Xanthophylls and eye health of infants and adults. J Med Liban. 2009 Oct-Dec;57(4):261-7.
Murthy KN et al. Comparative evaluation of hepatoprotective activity of carotenoids of microalgae. J Med Food. 2005 Winter;8(4):523-8.
Ye ZW, Jiang JG and Wu GH. Biosynthesis and regulation of carotenoids in Dunaliella: progresses and prospects. Biotechnol Adv. 2008 Jul-Aug;26(4):352-60
Burton GW et al. Human plasma and tissue alpha-tocopherol concentrations in response to supplementation with deuterated natural and synthetic vitamin E. Am J Clin Nutr. 1998 Apr;67(4):669-84.
Chopra RK and Bhagavan HN. Relative bioavailabilities of natural and synthetic vitamin E formulations containing mixed tocopherols in human subjects. Int J Vitam Nutr Res 1999; 69: 92-95.
Dietrich M et al. Does gamma-tocopherol play a role in the primary prevention of heart disease and cancer? A review. J Am Coll Nutr. 2006 Aug;25(4):292-9.
Jiang Q and Ames BN. Gamma-tocopherol, but not alpha-tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats. FASEB J. 2003 May;17(8):816-22.
Jiang Q et al. A combination of aspirin and gamma-tocopherol is superior to that of aspirin and alpha-tocopherol in anti-inflammatory action and attenuation of aspirin-induced adverse effects. J Nutr Biochem. 2009 Nov;20(11):894-900.
Jiang Q et al. gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis. Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17825-30.
Jiang Q et al. gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr. 2001 Dec;74(6):714-22
Landrier JF et al. Vitamin E decreases endogenous cholesterol synthesis and apo-AI-mediated cholesterol secretion in Caco-2 cells. J Nutr Biochem. 2010 Feb 8. [Epub ahead of print]
Lee HJ et al. Mixed tocopherols prevent mammary tumorigenesis by inhibiting estrogen action and activating PPAR-gamma. Clin Cancer Res. 2009 Jun 15;15(12):4242-9.
Reitera E, Jiang Q and Christen S. Anti-inflammatory properties of alpha- and gamma-tocopherol. Mol Aspects Med. 2007 Oct-Dec;28(5-6):668-91.
Wagner KH, Kamal-Eldin A and Elmadfa I. Gamma-tocopherol–an underestimated vitamin? Ann Nutr Metab. 2004;48(3):169-88.
Wolf G. How an increased intake of alpha-tocopherol can suppress the bioavailability of gamma-tocopherol. Nutr Rev. 2006 Jun;64(6):295-9
Yu W et al. Anticancer actions of natural and synthetic vitamin E forms: RRR-alpha-tocopherol blocks the anticancer actions of gamma-tocopherol. Mol Nutr Food Res. 2009 Dec;53(12):1573-81.
Pine Bark Extract
Canali R et al. The anti-inflammatory pharmacology of Pycnogenol in humans involves COX-2 and 5-LOX mRNA expression in leukocytes. Int Immunopharmacol. 2009 Sep;9(10):1145-9
Cisar P et al. Effect of pine bark extract (Pycnogenol) on symptoms of knee osteoarthritis. Phytother Res. 2008 Aug;22(8):1087-92
Devaraj S et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids. 2002 Oct;37(10):931-4.
Liu X, Zhou HJ and Rohdewald P. French maritime pine bark extract Pycnogenol dose-dependently lowers glucose in type 2 diabetic patients. Diabetes Care. 2004 Mar;27(3):839.
Liu X et al. Pycnogenol, French maritime pine bark extract, improves endothelial function of hypertensive patients. Life Sci. 2004 Jan 2;74(7):855-62.
Liu X et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci. 2004 Oct 8;75(21):2505-13.
Nishioka K et al. Pycnogenol, French maritime pine bark extract, augments endothelium-dependent vasodilation in humans. Hypertens Res. 2007 Sep;30(9):775-80.
Rohdewald P. review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther. 2002 Apr;40(4):158-68.
Rohdewald P and Beil W. In vitro inhibition of Helicobacter pylori growth and adherence to gastric mucosal cells by Pycnogenol. Phytother Res. 2008 May;22(5):685-8.
Schafer A et al. Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol). Biomed Pharmacother. 2006 Jan;60(1):5-9
Suzuki N et al. French maritime pine bark extract significantly lowers the requirement for analgesic medication in dysmenorrhea: a multicenter, randomized, double-blind, placebo-controlled study. J Reprod Med. 2008 May;53(5):338-46
Trebaticka J et al. Treatment of ADHD with French maritime pine bark extract, Pycnogenol. Eur Child Adolesc Psychiatry. 2006 Sep;15(6):329-35
Clifton PM. Effect of Grape Seed Extract and Quercetin on Cardiovascular and Endothelial Parameters in High-Risk Subjects. J Biomed Biotechnol 2004: 272-278, 2004.
Crespo I et al. A comparison of the effects of kaempferol and quercetin on cytokine-induced pro-inflammatory status of cultured human endothelial cells. Br J Nutr. 2008 Nov;100(5):968-76
Edwards RL et al. Quercetin reduces blood pressure in hypertensive subjects. J Nutr. 2007 Nov;137(11):2405-11.
Egert S et al. Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study. Br J Nutr. 2009 Oct;102(7):1065-74
Egert S et al. Serum lipid and blood pressure responses to quercetin vary in overweight patients by apolipoprotein E genotype. J Nutr. 2010 Feb;140(2):278-84
Nieman DC et al. Quercetin reduces illness but not immune perturbations after intensive exercise. Med Sci Sports Exerc. 2007 Sep;39(9):1561-9.
Perez-Vizcaino F, Duarte J, Andriantsitohaina R. Endothelial function and cardiovascular disease: effects of quercetin and wine polyphenols. Free Radic Res. 2006 Oct;40(10):1054-65.
Perez-Vizcaino F et al. Antihypertensive effects of the flavonoid quercetin. Pharmacol Rep. 2009 Jan-Feb;61(1):67-75.
Potenza L et al. Effect of quercetin on oxidative nuclear and mitochondrial DNA damage. Biofactors. 2008;33(1):33-48.
Allard JS et al. Dietary activators of Sirt1. Mol Cell Endocrinol. 2009 Feb 5;299(1):58-63.
Kaindl U et al. The dietary antioxidants resveratrol and quercetin protect cells from exogenous pro-oxidative damage. Food Chem Toxicol. 2008 Apr;46(4):1320-6
Karuppagounder SS et al. Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer’s disease. Neurochem Int. 2009 Feb;54(2):111-8
Losa GA. Resveratrol modulates apoptosis and oxidation in human blood mononuclear cells. Eur J Clin Invest. 2003 Sep;33(9):818-23.
Nicholson SK, Tucker GA and Brameld JM. Effects of dietary polyphenols on gene expression in human vascular endothelial cells. Proc Nutr Soc. 2008 Feb;67(1):42-7.
Shakibaei M et al. Resveratrol suppresses interleukin-1beta-induced inflammatory signaling and apoptosis in human articular chondrocytes: potential for use as a novel nutraceutical for the treatment of osteoarthritis. Biochem Pharmacol. 2008 Dec 1;76(11):1426-39
Wallerath T et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation. 2002 Sep 24;106(13):1652-8.
Wu JM et al. Mechanism of cardioprotection by resveratrol, a phenolic antioxidant present in red wine (Review). Int J Mol Med. 2001 Jul;8(1):3-17.
SOD Precursor System
DiSilvestro RA, Marten J and Skehan M. Effects of copper supplementation on ceruloplasmin and copper-zinc superoxide dismutase in free-living rheumatoid arthritis patients. J Am Coll Nutr 11: 177-180, 1992.
Tuncer S et al. Trace element and magnesium levels and superoxide dismutase activity in rheumatoid arthritis. Biol Trace Elem Res. 1999 May;68(2):137-42.
Vitamin and Mineral Blend
Chelated Mineral Research
Ashmead HD. The absorption and metabolism of iron amino acid chelate. Arch Latinoam Nutr. 2001 Mar;51(1 Suppl 1):13-21.
Ashmead SD. The chemistry of ferrous bis-glycinate chelate. Arch Latinoam Nutr. 2001 Mar;51(1 Suppl 1):7-12
Bovell-Benjamin AC, Viteri FE and Allen LH. Iron absorption from ferrous bisglycinate and ferric trisglycinate in whole maize is regulated by iron status. Am J Clin Nutr. 2000 Jun;71(6):1563-9.
Fox TE, Eagles J and Fairweather-Tait SJ. Bioavailability of iron glycine as a fortificant in infant foods. Am J Clin Nutr. 1998 Apr;67(4):664-8.
Gandia P et al. A bioavailability study comparing two oral formulations containing zinc (Zn bis-glycinate vs. Zn gluconate) after a single administration to twelve healthy female volunteers. Int J Vitam Nutr Res. 2007 Jul;77(4):243-8
Giorgini E et al. The use of sweet rolls fortified with iron bis-glycinate chelate in the prevention of iron deficiency anemia in preschool children. Arch Latinoam Nutr. 2001 Mar;51(1 Suppl 1):48-53.
Hertrampf E and Olivares M. Iron amino acid chelates. Int J Vitam Nutr Res. 2004 Nov;74(6):435-43.
Jeppsen R. Toxicology and safety of Ferrochel and other iron amino acid chelates. Arch Latinoam Nutr. 2001 Mar;51(1 Suppl 1):26-34.
Jeppsen RB and Borzelleca J. Safety evaluation of ferrous bisglycinate chelate. Food Chem Toxicol. 1999 Jul;37(7):723-31.
Layrisse M et al. Iron bioavailability in humans from breakfasts enriched with iron bis-glycine chelate, phytates and polyphenols. J Nutr. 2000 Sep;130(9):2195-9.
Mazariegos DI et al. The mechanisms for regulating absorption of Fe bis-glycine chelate and Fe-ascorbate in caco-2 cells are similar. J Nutr. 2004 Feb;134(2):395-8.
Melamed N et al. Iron supplementation in pregnancy–does the preparation matter? Arch Gynecol Obstet. 2007 Dec;276(6):601-4.
Miglioranza LH et al. Effect of long-term fortification of whey drink with ferrous bisglycinate on anemia prevalence in children and adolescents from deprived areas in Londrina, Paraná, Brazil. Nutrition. 2003 May;19(5):419-21.
Pineda O and Ashmead HD. Effectiveness of treatment of iron-deficiency anemia in infants and young children with ferrous bis-glycinate chelate. Nutrition. 2001 May;17(5):381-4.
Pizzaro F et al. Iron bis-glycine chelate competes for the nonheme-iron absorption pathway. Am J Clin Nutr. 2002 Sep;76(3):577-81.
Olivares et al. Milk inhibits and ascorbic acid favors ferrous bis-glycine chelate bioavailability in humans. J Nutr. 1997 Jul;127(7):1407-11.
Osman AK and al-Othaimeen A. Experience with ferrous bis-glycine chelate as an iron fortificant in milk. Int J Vitam Nutr Res. 2002 Jul;72(4):257-63.
Szarfarc SC et al. Relative effectiveness of iron bis-glycinate chelate (Ferrochel) and ferrous sulfate in the control of iron deficiency in pregnant women. Arch Latinoam Nutr. 2001 Mar;51(1 Suppl 1):42-7
Van Stuijvenberg ME et al. The efficacy of ferrous bisglycinate and electrolytic iron as fortificants in bread in iron-deficient school children. Br J Nutr. 2006 Mar;95(3):532-8.
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Digestive Health and Nutrient Bioavailablity
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Probiotics and Eczema
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Probiotics and GI Problems
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Probiotics and Immunity
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Probiotics and Lactose Intolerance
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Probiotics and Diarrhea
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Probiotics & H-Pylori/Ulcers
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Probiotics and IBS (Irritable Bowel Syndrome)
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